OBAGI - Tretinoin GEL 0.05%

Professional-Strength Tretinoin Gel for Acne, Fine Lines & Skin Renewal

This product requires a prescription. Medical assessment required.

Obagi Tretinoin 0.05% Gel is a clinically proven topical retinoid designed to accelerate skin cell turnover, helping to reduce the appearance of acne, fine lines and uneven texture while promoting a smoother, clearer complexion.

Formulated in a lightweight gel base, this treatment is ideal for those who prefer a fast-absorbing, non-greasy texture — particularly beneficial for oily, combination or blemish-prone skin. The gel delivery enables efficient penetration with controlled release of active tretinoin, supporting enhanced results with less surface irritation for many users.

This prescription-only formula should be incorporated into a comprehensive skincare plan under clinical supervision.

How It Works

Tretinoin (0.05%) — Retinoic Acid
As the gold-standard retinoid, tretinoin works at the cellular level to:

• Accelerate epidermal cell turnover
• Reduce comedones and breakouts
• Minimise fine lines and surface irregularities
• Improve skin texture and tone

By promoting faster shedding of old skin cells and stimulating collagen pathways, tretinoin helps reveal clearer, smoother skin over time.

Gel vs Cream — What’s the Difference?

Why choose the Gel formulation:

• Lighter texture — Ideal for combination and oily skin types
• Fast absorption — Less residue and minimal heaviness
• Less occlusive — Often better tolerated in humid climates
• Enhanced delivery — Gel bases can facilitate deeper penetration

Creams are richer and excellent for very dry or mature skin, but the gel version is frequently recommended if you’re concerned about oiliness, congestion or seasonal breakouts.

How to Use

Apply a pea-sized amount once daily, typically in the evening, to clean, dry skin. Start with alternate nights if sensitivity occurs. Always follow with broad-spectrum SPF during the day and avoid concurrent use of abrasive exfoliants without clinician advice.

Suitable For

• Oily and combination skin types
• Acne-prone or congested skin
• Those seeking lightweight retinoid delivery
• Users with prior retinoid experience

Not recommended during pregnancy or breastfeeding without clinician assessment.

Prescription & Clinical Support

Because Tretinoin Gel is prescription-only, purchase includes a clinician review and personalised treatment guidance to ensure safe and effective use. Your safety and outcomes are our priority.

Frequently Asked Questions

What is the difference between Obagi Tretinoin Gel 0.05% and Tretinoin Cream 0.025%?

The gel formulation at 0.05% is stronger and lighter in texture, making it better suited to oily, combination or acne-prone skin. The cream at 0.025% is gentler and richer, ideal for first-time retinoid users or those with dry or sensitive skin.

Do I need a prescription for Obagi Tretinoin Gel?

Yes — tretinoin is a prescription-only medicine in the UK. A medical assessment is required before purchase to confirm it is appropriate for your skin and health.

How often should I use tretinoin gel?

Start with alternate nights to allow your skin to adjust, then gradually increase to nightly use as tolerated. Always apply in the evening to clean, dry skin and use SPF every morning.

What side effects should I expect?

During the initial adjustment phase (typically 2–4 weeks), you may experience dryness, redness, or mild peeling. These are normal and usually subside as your skin adapts. If irritation becomes severe, reduce frequency and consult your prescriber.

Can I use tretinoin with vitamin C or niacinamide?

Apply tretinoin at night and vitamin C in the morning. Niacinamide can be used in the same routine and may help reduce redness. Avoid combining with strong exfoliating acids without professional guidance.

Is tretinoin gel safe during pregnancy?

No — tretinoin is not recommended during pregnancy or breastfeeding. Please consult your doctor for safe alternatives.