OBAGI - NU-GEN™ Cellular Renewal Serum

The Future of Skin Renewal — OBAGI NU-GEN™ Cellular Renewal Serum 30ml

Ageing isn't just about what happens on the surface of your skin — it happens at the cellular level. As we age, levels of NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme essential to cellular energy production and DNA repair, decline by up to 50% between the ages of 40 and 60. The result: slower cell turnover, reduced collagen synthesis, impaired DNA repair, and the visible signs of skin ageing that no amount of surface-level hydration can fully address.

OBAGI NU-GEN™ Cellular Renewal Serum is formulated to target this root cause. Powered by a NAD+ precursor complex alongside OBAGI's advanced peptide and antioxidant technology, it works at the cellular level to restore the skin's renewal capacity — visibly rewinding the appearance of aged skin with consistent use. This is not anti-ageing skincare. This is cellular renewal.

The Science Behind NU-GEN™

NAD+ is one of the most researched molecules in longevity science, studied extensively at institutions including Harvard Medical School and the National Institutes of Health. It plays a critical role in:

• Cellular energy metabolism — powering the mitochondria that drive every skin cell function, from collagen production to barrier repair
• DNA repair mechanisms — activating enzymes (PARPs) that identify and repair DNA damage caused by UV exposure, pollution, and oxidative stress
• Sirtuin activation — proteins associated with cellular longevity, stress resistance, and the regulation of inflammation
• Skin cell renewal cycle regulation — supporting the natural turnover rate that slows significantly with age

By delivering NAD+ precursors topically, NU-GEN™ helps replenish what time depletes — supporting the skin's ability to renew, repair, and regenerate at a cellular level rather than simply masking the effects of ageing at the surface.

Key Benefits

• NAD+ cellular renewal technology — targets the root biological cause of skin ageing
• Visibly rewinds skin age — clinically shown to improve the appearance of aged skin
• Restores radiance and skin tone — replenishes the luminosity lost through cellular energy decline
• Strengthens skin resilience — supports the skin's natural defence, repair, and stress-resistance mechanisms
• Advanced peptide complex — stimulates collagen and elastin synthesis for firmer, more youthful-looking skin
• Multi-layered antioxidant protection — neutralises free radical damage from UV, blue light, pollution, and infrared radiation
• Supports the skin barrier — hydrating base delivers actives while maintaining barrier integrity
• OBAGI Medical formulation — developed by the brand trusted by aesthetic clinicians and dermatologists worldwide

Key Ingredients

NAD+ Precursor Complex

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell, essential to energy production, DNA repair, and cellular longevity. Levels decline by up to 50% between the ages of 40 and 60 — a decline directly linked to reduced skin cell renewal, impaired collagen synthesis, and the accumulation of visible ageing. NU-GEN™ delivers NAD+ precursors topically to help replenish this decline, supporting the skin's cellular renewal machinery from within.

Advanced Peptide Complex

A targeted blend of bioactive signal peptides that communicate directly with fibroblasts — the skin cells responsible for producing collagen, elastin, and hyaluronic acid. By stimulating fibroblast activity, the peptide complex supports genuine structural renewal rather than surface-level plumping.

Antioxidant Complex

A multi-layered antioxidant system formulated to neutralise free radicals generated by UV exposure, blue light, infrared radiation, pollution, and metabolic processes. Antioxidant protection is particularly critical in the context of NAD+ biology — oxidative stress is one of the primary drivers of NAD+ depletion, creating a cycle of cellular decline that NU-GEN™ is designed to interrupt.

How to Use

1. Cleanse and tone the skin thoroughly.
2. Apply a small amount to the face and neck, morning and/or evening.
3. Gently press into the skin — do not rub.
4. Follow with moisturiser and, in the morning, a broad-spectrum SPF 30+ sunscreen.
5. For best results, use consistently as part of a daily skincare routine.

Can be used alongside other OBAGI products including the Nu-Derm® System and Professional-C® Serums. For a personalised protocol, consult one of our skincare specialists.

Frequently Asked Questions

What is NAD+ and why does it matter for skin ageing?

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every cell of the body, playing a critical role in energy production, DNA repair, and the activation of longevity-associated proteins called sirtuins. NAD+ levels decline significantly with age — by up to 50% between the ages of 40 and 60 — leading to slower cell turnover, reduced collagen synthesis, impaired DNA repair, and the visible signs of skin ageing. Topical NAD+ precursors help replenish this decline, supporting the skin's cellular renewal processes at a biological level.

How is OBAGI NU-GEN™ different from other anti-ageing serums?

Most anti-ageing serums address the symptoms of skin ageing — fine lines, dullness, loss of firmness — at the surface level. NU-GEN™ targets the underlying biological cause: the decline of cellular energy and repair capacity driven by NAD+ depletion. By restoring the skin's cellular renewal machinery rather than simply masking the effects of ageing, NU-GEN™ delivers improvements that compound with continued use.

Is OBAGI NU-GEN™ the same as taking NAD+ supplements?

No — but the science is related. Oral NAD+ precursor supplements (such as NMN and NR) work systemically via the bloodstream. NU-GEN™ delivers NAD+ precursors topically, targeting the skin's cellular environment directly. Topical delivery allows for concentrated local action in the skin without systemic effects, making it a complementary approach to oral supplementation rather than a replacement.

Can OBAGI NU-GEN™ be used with tretinoin or other prescription actives?

Yes. NU-GEN™ is designed to complement OBAGI's broader skincare ecosystem, including prescription tretinoin formulations. The recommended approach is to apply NU-GEN™ in the morning and tretinoin in the evening. Consult your skincare professional for a personalised protocol.

Can I use NU-GEN™ alongside the OBAGI Nu-Derm® System?

Yes. NU-GEN™ integrates seamlessly with the Nu-Derm® System, adding a cellular renewal dimension to the system's established brightening and resurfacing protocol. Apply NU-GEN™ as a serum step before your Nu-Derm® moisturiser.

Is NU-GEN™ suitable for sensitive skin?

NU-GEN™ is formulated by OBAGI Medical with tolerability in mind. As with any active serum, we recommend patch testing before full application, particularly for those with reactive or sensitive skin. Consult one of our skincare specialists if unsure.

How long does it take to see results from OBAGI NU-GEN™?

Most users notice improvements in skin radiance, texture, and hydration within 4–6 weeks of consistent daily use. More significant improvements in fine lines, firmness, and overall skin appearance are typically visible at 8–12 weeks. Results continue to improve with ongoing use as cellular renewal capacity is progressively restored.

What is the difference between OBAGI NU-GEN™ and OBAGI Professional-C® Serum?

These products target different aspects of skin ageing and work well together. Professional-C® Serum uses L-Ascorbic Acid to brighten skin, neutralise free radicals, and stimulate collagen at the antioxidant level. NU-GEN™ works at the cellular energy level, targeting the NAD+ decline that underlies the broader ageing process. Used together — Professional-C® in the morning, NU-GEN™ morning or evening — they address skin ageing from complementary angles.

Why should I buy OBAGI from Skin by Science rather than another retailer?

Skin by Science is an authorised UK OBAGI stockist. All products are sourced directly through official OBAGI channels, ensuring authenticity, correct storage conditions, and full manufacturer support. Purchasing OBAGI from unauthorised retailers risks receiving counterfeit, expired, or improperly stored products that may be ineffective or unsafe.

Is OBAGI NU-GEN™ available on prescription?

No. OBAGI NU-GEN™ Cellular Renewal Serum is an over-the-counter (OTC) cosmeceutical product and does not require a prescription. If you are looking for OBAGI's prescription-strength products such as tretinoin formulations, please visit our prescription consultation service.

Further Information

Product formulations may be updated from time to time. For accurate ingredient information, refer to your product packaging. For personalised skincare advice or to build a complete OBAGI protocol tailored to your skin concerns, consult one of our skincare specialists at Skin by Science.