Alastin TriHex & TriHex+ Explained | UK Product Guide

ALASTIN TriHex Technology is a proprietary peptide and botanical platform designed to help clear damaged collagen and elastin fragments while supporting the skin’s natural production of new, healthy collagen and elastin.

TriHex+ is the next generation of this technology. Used in the updated ALASTIN Restorative Skin Complex 2.0, it adds proprietary Octapeptide-45 to support high-molecular-weight hyaluronic acid alongside collagen and elastin renewal.

This guide explains how TriHex works, what distinguishes TriHex+ and which technology appears in the current UK ALASTIN products available through Skin By Science.

Current UK formulation distinction: Restorative Skin Complex 2.0 is the updated 29ml product with TriHex+ and new packaging. Restorative Eye Complex, Restorative Neck Complex, Skin Nectar and Ultra Nourishing Moisturiser retain their established, product-specific TriHex formulations.

What Is ALASTIN TriHex Technology?

TriHex Technology is ALASTIN’s proprietary combination of active peptides and botanicals, developed to support the extracellular matrix and the natural processes involved in producing collagen and elastin.

The extracellular matrix is the structural environment surrounding skin cells. It contains proteins and other components that contribute to the skin’s firmness, elasticity, hydration and overall quality.

Ageing, ultraviolet exposure and environmental stress can damage collagen and elastin. Fragments of these damaged proteins can accumulate within the extracellular matrix, creating a less favourable environment for the production of new structural proteins.

TriHex Technology is designed around a three-stage process:

Remove: support the clearance of aged and damaged collagen and elastin fragments.
Rebuild: create a more favourable extracellular environment for new collagen and elastin.
Replenish: support the continued natural production of healthy structural proteins through consistent use.

The Remove, Rebuild and Replenish Approach

1. Remove Damaged Collagen and Elastin

Collagen and elastin become damaged and fragmented through intrinsic ageing, ultraviolet exposure and other environmental influences. These fragments can collect within the skin’s extracellular environment.

TriHex incorporates peptides including Tripeptide-1 and Hexapeptide-12 to support the skin’s natural processes for clearing aged collagen and elastin fragments. ALASTIN describes this as preparing the skin bed for renewed protein production.

2. Rebuild a Healthier Skin Environment

Clearing damaged protein fragments creates space within the extracellular matrix and helps establish a more favourable environment for regeneration.

TriHex then supports the skin’s ability to produce new collagen and elastin. Visible results associated with this process can include improvements in:

Fine lines and wrinkles.
Skin texture and surface smoothness.
Visible firmness.
Elasticity and resilience.
Hydration.
Thinning or less supported-looking skin.

3. Replenish Collagen and Elastin

Daily use supports an ongoing cycle of clearance and renewal. This continued replenishment is central to the role of TriHex in ALASTIN’s daily rejuvenating products.

Rather than addressing only surface moisture or temporarily smoothing the complexion, TriHex formulations are positioned around the biological environment associated with longer-term visible skin quality.

Why Collagen and Elastin Matter

Collagen and elastin perform different but complementary structural roles within the skin.

Collagen

Collagen provides tensile strength and structural support. Changes in collagen quantity, quality and organisation contribute to fine lines, wrinkles, reduced firmness and uneven skin texture.

Elastin

Elastin allows skin to stretch and return towards its original shape. Healthy elastic fibres contribute to resilience, recoil and a visibly lifted appearance.

Elastin has an especially slow natural turnover rate. This makes technology focused on both clearing damaged elastin and supporting renewed elastin production a distinctive feature of the ALASTIN platform.

What Is TriHex+?

TriHex+ is ALASTIN’s next-generation TriHex technology, enhanced with proprietary Octapeptide-45.

The original TriHex platform focuses on damaged collagen and elastin clearance followed by support for new collagen and elastin. TriHex+ retains this foundation while extending the technology to support the skin’s natural production of high-molecular-weight hyaluronic acid.

TriHex+ therefore targets three components central to youthful-looking skin:

Collagen for structural support, firmness and smoothness.
Elastin for elasticity, recoil and resilience.
High-molecular-weight hyaluronic acid for long-lasting hydration and visible plumpness.

TriHex versus TriHex+: The Key Differences

Feature	TriHex Technology	TriHex+
Core approach	Remove, rebuild and replenish	Enhanced remove, rebuild and replenish platform
Collagen support	Supports natural production of new collagen	Enhanced collagen support with Octapeptide-45
Elastin support	Supports damaged-fragment clearance and new elastin production	Enhanced elastin support with Octapeptide-45
Hyaluronic acid	Hydration depends on the complete product formulation	Supports natural high-molecular-weight HA production
Current UK products	Selected eye, neck, moisturising and procedure-support formulations	Restorative Skin Complex 2.0, 29ml

What Does Octapeptide-45 Add to TriHex+?

Octapeptide-45 is a proprietary ALASTIN peptide that supports the skin’s natural production of high-molecular-weight hyaluronic acid. Within TriHex+, it also enhances support for collagen and elastin production.

Hyaluronic acid contributes to the skin’s moisture content, suppleness and visible plumpness. Combining HA support with collagen and elastin technology allows TriHex+ to address structural and hydration-related features of visible skin ageing together.

Octapeptide-45 is also central to ALASTIN HA IMMERSE Serum, where it is combined with topical hyaluronic acid and HA-preserving technology for immediate and progressive hydration.

Read our dedicated guide to Octapeptide-45 and hyaluronic acid in ALASTIN HA IMMERSE.

Which UK ALASTIN Product Uses TriHex+?

The current TriHex+ facial treatment available through Skin By Science is ALASTIN Restorative Skin Complex 2.0.

This updated 29ml formula combines:

TriHex+ with proprietary Octapeptide-45.
Magnolol for support of healthy facial adipose tissue and visible volumisation.
Niacinamide for antioxidant and visible tone support.
Ceramides for moisture retention and barrier support.
A sophisticated complex of additional peptides and antioxidants.

It targets skin texture, tone, volume, hydration, elasticity, fine lines and wrinkles, making it the principal multi-tasking facial serum within the ALASTIN range.

Magnolol and the Updated Restorative Skin Complex

Magnolol adds another distinctive pathway to Restorative Skin Complex 2.0. ALASTIN includes it to support the body’s natural production of healthy facial adipose tissue and improve the appearance of skin plumpness and volume.

This works alongside TriHex+ through three complementary areas:

Collagen and elastin support for visible structure and elasticity.
High-molecular-weight HA support for hydration and plumpness.
Magnolol for visible volumisation in thinning skin.

This makes Restorative Skin Complex 2.0 particularly relevant where ageing or weight change has contributed to thinner-looking, less firm or less full-looking skin.

Which UK Products Retain Original TriHex Technology?

The introduction of TriHex+ in Restorative Skin Complex does not mean the entire UK ALASTIN range has changed. Several established products retain their original, product-specific TriHex formulations.

ALASTIN Restorative Eye Complex

ALASTIN Restorative Eye Complex uses TriHex Technology within a targeted eye-area formulation. It addresses fine lines, wrinkles, puffiness, dark circles and visible thinning around the eyes.

ALASTIN Restorative Neck Complex

ALASTIN Restorative Neck Complex combines TriHex Technology with ingredients selected for the neck and décolleté. It targets crepey texture, discolouration, fine lines, wrinkles and visible laxity.

Read our complete guide to Restorative Neck Complex, TriHex and crepey neck skin.

ALASTIN Skin Nectar

ALASTIN Skin Nectar with TriHex Technology is designed for clinician-directed use around aesthetic procedures. It supports the skin’s extracellular environment and helps prepare the skin for treatment and recovery.

ALASTIN Ultra Nourishing Moisturiser

ALASTIN Ultra Nourishing Moisturiser combines TriHex Technology with a rich moisturising base to support dry, compromised or post-procedure skin.

ALASTIN Products with Other Proprietary Technologies

Not every ALASTIN product uses TriHex. The wider range includes other targeted technologies designed for different concerns.

HA IMMERSE and Octapeptide-45

HA IMMERSE Serum centres on Octapeptide-45, topical hyaluronic acid and HA-preserving ingredients for immediate hydration and progressive visible plumping.

A-Luminate and PATH-3 Technology

ALASTIN A-Luminate Brightening Serum uses PATH-3 Technology, liposomal tranexamic acid and niacinamide to target the appearance of dark spots, uneven pigmentation and visible redness.

These technologies can sit within the same clinical skincare programme while retaining clearly differentiated roles.

What Visible Results Are Associated with TriHex?

Across its product-specific formulations, TriHex Technology is used to support improvements in:

The appearance of fine lines and wrinkles.
Visible firmness and elasticity.
Skin texture and smoothness.
Hydration and suppleness.
Dullness and uneven-looking tone.
The appearance of thinning skin.
Visible skin quality before and after selected aesthetic procedures.

The precise benefits depend on the finished product. Restorative Eye Complex concentrates TriHex within an eye treatment, Restorative Neck Complex combines it with neck-specific technology, and Restorative Skin Complex 2.0 uses TriHex+ within a comprehensive facial rejuvenating serum.

Clinical Evidence Behind TriHex Technology

The scientific rationale for TriHex has been discussed in peer-reviewed literature examining extracellular-matrix modulation and the optimisation of skin around rejuvenating procedures.

Published clinical research has also evaluated individual TriHex formulations in areas including:

Visible eye-area ageing.
Skin preparation and recovery around procedures.
Radiofrequency microneedling support.
Post-injection skincare.
Body skin texture and firmness.
Daily facial, neck and décolleté care.

ALASTIN reports more than 60 scientific studies, multiple patented formulations and an extensive network of physician partners supporting the development of its regenerative skincare platform.

Clinical Results for Restorative Skin Complex with TriHex+

In an ALASTIN clinical study, Restorative Skin Complex with TriHex+ produced the following participant-reported results in as early as 12 weeks:

98% agreed that it improved skin hydration.
89% reported improvements in overall skin texture.
93% reported overall satisfaction.

Clinical photography also documented visible improvement in surface roughness, redness, fine lines and wrinkles, skin dullness and loss of volume.

TriHex and Aesthetic Procedures

Selected TriHex products are specifically formulated for use around aesthetic procedures. The remove, rebuild and replenish framework is relevant in this setting because procedures create controlled changes within the skin while relying on organised recovery and remodelling.

ALASTIN procedure-support products are used by practitioners around treatments such as:

Laser and light-based procedures.
Microneedling and radiofrequency microneedling.
Injectable treatments.
Skin resurfacing procedures.
Selected surgical procedures.

The specific product and application schedule should be selected according to the procedure and the treating practitioner’s protocol.

Can TriHex Be Used in a Daily Skincare Routine?

Yes. TriHex was developed for both daily regenerative skincare and procedure-support applications.

A comprehensive ALASTIN routine may include:

A suitable cleanser.
HA IMMERSE Serum for advanced hydration.
Restorative Skin Complex 2.0 for multi-targeted facial rejuvenation.
A-Luminate Brightening Serum for uneven tone and discolouration.
A targeted eye or neck treatment where required.
Ultra Nourishing Moisturiser for additional moisture and barrier support.
Broad-spectrum sunscreen every morning.

The complete skincare layering guide explains how to order serums, moisturisers and sunscreen within a multi-product routine.

Can TriHex Be Used with Retinoids and Vitamin C?

TriHex products can be incorporated into routines containing other established skincare ingredients, including retinoids, vitamin C, hyaluronic acid and targeted brightening products.

The appropriate sequence depends on the product textures. In general, lighter hydration serums are applied first, followed by treatment serums, moisturiser and morning sunscreen.

TriHex’s collagen-, elastin- and extracellular-matrix focus gives it a distinct role alongside ingredients that concentrate on cellular turnover, antioxidant protection, pigmentation or exfoliation.

Frequently Asked Questions

What does TriHex Technology do?

TriHex supports the clearance of damaged collagen and elastin fragments while helping the skin naturally produce new, healthy collagen and elastin. Its remove, rebuild and replenish cycle supports visible firmness, elasticity, smoothness and skin quality.

What is the difference between TriHex and TriHex+?

TriHex+ enhances the original collagen- and elastin-focused platform with Octapeptide-45, adding support for the skin’s natural production of high-molecular-weight hyaluronic acid.

Which ALASTIN product currently contains TriHex+ in the UK?

The updated 29ml ALASTIN Restorative Skin Complex 2.0 contains TriHex+ and is supplied in the new packaging.

Have all UK ALASTIN products changed to TriHex+?

No. The current UK Restorative Eye Complex, Restorative Neck Complex, Skin Nectar and Ultra Nourishing Moisturiser retain their individual original TriHex formulations.

What peptides are central to original TriHex?

Tripeptide-1 and Hexapeptide-12 are central peptides within the original TriHex platform, supporting damaged-protein clearance and the natural production of new collagen and elastin.

What does Octapeptide-45 do?

Octapeptide-45 supports the skin’s natural production of high-molecular-weight hyaluronic acid. Within TriHex+, it also enhances collagen and elastin support.

Does TriHex help thinning skin?

Yes. TriHex formulations support collagen, elastin, hydration and visible elasticity, helping improve the appearance of thin, less firm or less resilient-looking skin.

Does TriHex support elastin?

Yes. Elastin support is one of the defining features of TriHex Technology. The platform helps clear damaged elastin fragments and supports the skin’s natural production of new elastin.

Can TriHex be used around aesthetic procedures?

Yes. Selected TriHex products are specifically developed for preparation and recovery around professional procedures. Use the product and schedule recommended for the treatment being performed.

Can different TriHex products be used together?

Yes. The products are formulated for different areas and purposes, allowing a facial serum, eye treatment, neck treatment and moisturiser to perform complementary roles within one ALASTIN routine.

Explore ALASTIN Technology and Products

ALASTIN has developed a connected range of regenerative skincare technologies addressing collagen, elastin, hyaluronic acid, pigmentation, hydration and treatment support.

Explore the complete ALASTIN skincare collection or use the related resources below to examine individual technologies and formulations.

Related ALASTIN products and technology guides

Sources Consulted

ALASTIN Skincare: TriHex Technology remove, rebuild and replenish information.
ALASTIN Skincare: Restorative Skin Complex with TriHex+ formulation and clinical results.
ALASTIN Skincare: Octapeptide-45 technology information.
Widgerow AD, Fabi SG, Palestine RF, et al. Extracellular Matrix Modulation: Optimizing Skin Care and Rejuvenation Procedures. Journal of Drugs in Dermatology. 2016;15(4 Suppl):s63–s71.
Reivitis A, Karimi K, Griffiths C, Banayan A. Clinical evaluation of a TriHex peptide- and botanical-containing eye treatment. Journal of Cosmetic Dermatology. 2018;17(3):467–470.

This article provides general skincare education. Follow the directions supplied with your UK product and the individual instructions provided by your treating practitioner around aesthetic procedures.