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In short: A 0.5% retinol cream from Obagi that releases retinol gradually to smooth fine lines, wrinkles and rough texture with minimal irritation. It is the middle strength between Retinol + PHA (0.3%) and Retinol 1.0.
Obagi Retinol 0.5 is a cream-based 0.5% retinol for evening use. It renews the skin and gradually releases its actives to reduce the look of fine lines and wrinkles and promote skin turnover, with minimal irritation. Calendula, green tea, chamomile, bisabolol and hyaluronic acid help keep skin comfortable.
It is a good next step once your skin is used to Retinol + PHA, before moving to Retinol 1.0. Retinol is a cosmetic retinoid, not prescription tretinoin. Genuine Obagi Medical stock from Obagi’s UK distribution.
Full ingredients (Obagi Medical, obagi.com): water (aqua), caprylic/capric triglyceride, glyceryl stearate, cyclopentasiloxane, butylene glycol, stearic acid, polysorbate 60, butyrospermum parkii (shea) butter, glycerin, stearyl alcohol, cyclohexasiloxane, dimethicone, retinol, calendula officinalis flower extract, camellia sinensis leaf extract, chamomilla recutita (matricaria) flower extract, dipotassium glycyrrhizate, sodium hyaluronate, tocopheryl acetate, bisabolol, ascorbic acid, carthamus tinctorius (safflower) seed oil, sorbitol, glyceryl acrylate/acrylic acid copolymer, dimethicone/vinyl dimethicone crosspolymer, allyl methacrylates crosspolymer, caprylyl glycol, ethylhexylglycerin, hexylene glycol, polysorbate 20, carbomer, disodium EDTA, triethanolamine, BHT, phenoxyethanol. Always check the pack you receive, as formulations can change.
New to retinol: Retinol + PHA (0.3%). Some experience: Retinol 0.5. Experienced users: Retinol 1.0.
Mild redness, peeling or irritation can happen as skin adjusts. Obagi suggests every-other-night use until it settles.
Yes. Use vitamin C in the morning and retinol at night.
No. This is a cosmetic Obagi product, so you can add it to your basket and check out as normal.
Reviewed 10 November 2026 by Skin by Science against Obagi Medical product information. Cosmetic product, not a medicine. No prescription or consultation needed.